Quantitative modeling of chronic myeloid leukemia: insights from radiobiology

Quantitative modeling of chronic myeloid leukemia: insights from radiobiology.

Mathematical models of chronic myeloid leukemia (CML) cell population dynamics are being developed to improve CML understanding and treatment. We review such models in light of relevant findings from radiobiology, emphasizing 3 points. First, the CML models almost all assert that the latency time, from CML initiation to diagnosis, is at most ∼10 years. Meanwhile, current radiobiologic estimates...

Supplement to “Quantitative modeling of chronic myeloid leukemia: insights from radiobiology”

Oncogenic signaling: new insights and controversies from chronic myeloid leukemia

JEM © The Rockefeller University Press $15.00 Vol. 204, No. 3, March 19, 2007 461–465 www.jem.org/cgi/doi/10.1084/jem.20062335 461 Chronic myeloid leukemia (CML), which is caused by the BCR–ABL fusion tyrosine kinase, is one of the most intensively studied human cancers. ABL kinase inhibitors have been spectacularly successful in treating CML, but disease persistence and acquired drug resistanc...

Oncogenic signaling: new insights and controversies from chronic myeloid leukemia

Chronic myeloid leukemia (CML), which is caused by the BCR-ABL fusion tyrosine kinase, is one of the most intensively studied human cancers. ABL kinase inhibitors have been spectacularly successful in treating CML, but disease persistence and acquired drug resistance can prevent eradication and cure of the leukemia. The development of better therapies will depend on a full understanding of sign...

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...